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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5481 | TRi-1 | Others | |
TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy | |||
T60446 | LCS3 | Apoptosis , Glutathione reductase | |
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, in... | |||
T4414 | Eprenetapopt | APR-246,PRIMA-1Met | Apoptosis , Others , Ferroptosis , p53 , Autophagy |
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c... | |||
T11130 | DVD-445 | Others | |
Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M. | |||
T75351 | TP-TRFS | ||
TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) [1] . | |||
T61647 | TrxR-IN-5 | ||
TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. A... | |||
T36399 | PAO-Nap | ||
PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting o... | |||
T79198 | S-Gem | Nucleoside Antimetabolite/Analog | |
S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity than Gemcitabine [1]. | |||
T73825 | TRFS-green | ||
TRFS-green, a highly selective off-on fluorescent probe, is designed for the specific imaging of thioredoxin reductase (TrxR) in living cells, exhibiting its maximum absorbance at approximately 373 nm [1]. | |||
T73512 | ZC0109 | ||
ZC0109, a dual inhibitor targeting IDO1 and Thioredoxin Reductase 1 (TrxR1) with IC50 values of 50 nM and 3.0 μM respectively, effectively promotes ROS accumulation and arrests the cell cycle at the G1/S phase, culminati... | |||
T78158 | MitoCur-1 | Others | |
MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compoun... |